Course disputée sur le circuit de Assen
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 1 | Casey Stoner | Ducati Marlboro Team | 08:25:37 | 26 | 25 | 1 |
| 2 | 2 | Dani Pedrosa | Repsol Honda Team | 11:34:07 | 26 | 20 | 2 |
| 3 | 5 | Colin Edwards | Tech3 Yamaha | 13:11:02 | 26 | 16 | 6 |
| 4 | 69 | Nicky Hayden | Repsol Honda Team | 14:06:54 | 26 | 13 | 4 |
| 5 | 4 | Andrea Dovizioso | Jir Team Scot MotoGP | 16:01:23 | 26 | 11 | 11 |
| 6 | 48 | Jorge Lorenzo | Fiat Yamaha Team | 16:22:25 | 26 | 10 | 7 |
| 7 | 7 | Chris Vermeulen | Rizla Suzuki MotoGP | 17:24:27 | 26 | 9 | 8 |
| 8 | 56 | Shinya Nakano | San Carlo Honda Gresini | 18:07:09 | 26 | 8 | 9 |
| 9 | 52 | James Toseland | Tech3 Yamaha | 19:08:23 | 26 | 7 | 13 |
| 10 | 50 | Sylvain Guintoli | Alice Team | 19:12:34 | 26 | 6 | 10 |
| 11 | 46 | Valentino Rossi | Fiat Yamaha Team | 21:12:42 | 26 | 5 | 3 |
| 12 | 24 | Toni Elias | Alice Team | 21:49:10 | 26 | 4 | 14 |
| 13 | 33 | Marco Melandri | Ducati Marlboro Team | 00:58:51 | 26 | 3 | 17 |
| 14 | 13 | Anthony West | Kawasaki Racing Team | 03:49:43 | 19 | 0 | 16 |
| 15 | 14 | Randy De Puniet | LCR Honda MotoGP | 01:00:00 | 0 | 0 | 5 |
| 16 | 15 | Alex De Angelis | San Carlo Honda Gresini | 01:00:00 | 0 | 0 | 12 |