Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 58 | Marco Simoncelli | Metis Gilera | 45'43.599 | 26 | 25 | 3 |
| 2 | 4 | Hiroshi Aoyama | Scot Racing Team 250cc | 45'45.542 | 26 | 20 | 2 |
| 3 | 19 | Alvaro Bautista | Mapfre Aspar Team | 45'48.260 | 26 | 16 | 6 |
| 4 | 63 | Mike Di Meglio | Mapfre Aspar Team | 45'56.375 | 26 | 13 | 1 |
| 5 | 15 | Roberto Locatelli | Metis Gilera | 45'59.074 | 26 | 11 | 12 |
| 6 | 40 | Hector Barbera | Pepe World Team | 46'03.070 | 26 | 10 | 4 |
| 7 | 52 | Lukas Pesek | Auto Kelly - CP | 46'06.281 | 26 | 9 | 11 |
| 8 | 55 | Hector Faubel | Valencia CF - Honda SAG | 46'16.408 | 26 | 8 | 10 |
| 9 | 12 | Thomas Luthi | Emmi - Caffe Latte | 46'32.920 | 26 | 7 | 14 |
| 10 | 17 | Karel Abraham | Cardion AB Motoracing | 46'33.444 | 26 | 6 | 16 |
| 11 | 35 | Raffaele De Rosa | Scot Racing Team 250cc | 46'37.166 | 26 | 5 | 15 |
| 12 | 25 | Alex Baldolini | WTR San Marino Team | 47'13.316 | 26 | 4 | 13 |
| 13 | 53 | Valentin Debise | CIP Moto - GP250 | 47'21.436 | 26 | 3 | 17 |
| 14 | 7 | Alex Pons | Pepe World Team | 47'30.271 | 26 | 2 | 18 |
| 15 | 56 | Vladimir Leonov | Viessmann Kiefer Racing | 47'30.420 | 26 | 1 | 21 |
| 16 | 11 | Balazs Nemeth | Balatonring Team | 46'09.367 | 25 | 0 | 20 |
| 17 | 10 | Imre Toth | Team Toth Aprilia | 46'38.325 | 25 | 0 | 19 |
| 18 | 29 | Barrett Long | Longevity Racing | 47'03.849 | 25 | 0 | 24 |
| 19 | 30 | Adam Roberts | Rat Racing | 47'04.092 | 25 | 0 | 23 |
| 20 | 14 | Ratthapark Wilairot | Thai Honda PTT SAG | 40'49.351 | 23 | 0 | 9 |
| 21 | 6 | Alex Debon | Aeropuerto-Castello-Blusens | 32'03.283 | 18 | 0 | 8 |
| 22 | 16 | Jules Cluzel | Matteoni Racing | 12'26.371 | 7 | 0 | 5 |
| 23 | 75 | Mattia Pasini | Team Toth Aprilia | 10'59.646 | 5 | 0 | 7 |
| 24 | 8 | Bastien Chesaux | Racing Team Germany | 0 | 0 | 22 |