Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 58 | Marco Simoncelli | Metis Gilera | 19:06:39 | 26 | 25 | 3 |
| 2 | 4 | Hiroshi Aoyama | Scot Racing Team 250cc | 19:39:02 | 26 | 20 | 2 |
| 3 | 19 | Alvaro Bautista | Mapfre Aspar Team | 20:24:20 | 26 | 16 | 6 |
| 4 | 63 | Mike Di Meglio | Mapfre Aspar Team | 22:39:35 | 26 | 13 | 1 |
| 5 | 15 | Roberto Locatelli | Metis Gilera | 23:24:34 | 26 | 11 | 12 |
| 6 | 40 | Hector Barbera | Pepe World Team | 00:31:10 | 26 | 10 | 4 |
| 7 | 52 | Lukas Pesek | Auto Kelly - CP | 01:24:41 | 26 | 9 | 11 |
| 8 | 55 | Hector Faubel | Valencia CF - Honda SAG | 04:13:28 | 26 | 8 | 10 |
| 9 | 12 | Thomas Luthi | Emmi - Caffe Latte | 08:48:40 | 26 | 7 | 14 |
| 10 | 17 | Karel Abraham | Cardion AB Motoracing | 08:57:24 | 26 | 6 | 16 |
| 11 | 35 | Raffaele De Rosa | Scot Racing Team 250cc | 09:59:26 | 26 | 5 | 15 |
| 12 | 25 | Alex Baldolini | WTR San Marino Team | 20:01:56 | 26 | 4 | 13 |
| 13 | 53 | Valentin Debise | CIP Moto - GP250 | 22:17:16 | 26 | 3 | 17 |
| 14 | 7 | Alex Pons | Pepe World Team | 00:44:31 | 26 | 2 | 18 |
| 15 | 56 | Vladimir Leonov | Viessmann Kiefer Racing | 00:47:00 | 26 | 1 | 21 |
| 16 | 11 | Balazs Nemeth | Balatonring Team | 02:16:07 | 25 | 0 | 20 |
| 17 | 10 | Imre Toth | Team Toth Aprilia | 10:18:45 | 25 | 0 | 19 |
| 18 | 29 | Barrett Long | Longevity Racing | 17:24:09 | 25 | 0 | 24 |
| 19 | 30 | Adam Roberts | Rat Racing | 17:28:12 | 25 | 0 | 23 |
| 20 | 14 | Ratthapark Wilairot | Thai Honda PTT SAG | 09:22:31 | 23 | 0 | 9 |
| 21 | 6 | Alex Debon | Aeropuerto-Castello-Blusens | 07:14:43 | 18 | 0 | 8 |
| 22 | 16 | Jules Cluzel | Matteoni Racing | 16:19:31 | 7 | 0 | 5 |
| 23 | 75 | Mattia Pasini | Team Toth Aprilia | 16:14:06 | 5 | 0 | 7 |
| 24 | 8 | Bastien Chesaux | Racing Team Germany | 01:00:00 | 0 | 0 | 22 |