Course disputée sur le circuit de Misano World Circuit Marco Simoncelli
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 46 | Valentino Rossi | Fiat Yamaha Team | 44'41.884 | 28 | 25 | 2 |
| 2 | 48 | Jorge Lorenzo | Fiat Yamaha Team | 44'45.047 | 28 | 20 | 3 |
| 3 | 24 | Toni Elias | Alice Team | 44'53.589 | 28 | 16 | 5 |
| 4 | 2 | Dani Pedrosa | Repsol Honda Team | 44'59.354 | 28 | 13 | 6 |
| 5 | 7 | Chris Vermeulen | Rizla Suzuki MotoGP | 45'05.293 | 28 | 11 | 7 |
| 6 | 52 | James Toseland | Tech3 Yamaha | 45'08.092 | 28 | 10 | 9 |
| 7 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 45'08.708 | 28 | 9 | 11 |
| 8 | 4 | Andrea Dovizioso | Jir Team Scot MotoGP | 45'09.475 | 28 | 8 | 14 |
| 9 | 33 | Marco Melandri | Ducati Marlboro Team | 45'15.053 | 28 | 7 | 15 |
| 10 | 5 | Colin Edwards | Tech3 Yamaha | 45'18.413 | 28 | 6 | 10 |
| 11 | 50 | Sylvain Guintoli | Alice Team | 45'23.965 | 28 | 5 | 12 |
| 12 | 56 | Shinya Nakano | San Carlo Honda Gresini | 45'25.692 | 28 | 4 | 8 |
| 13 | 13 | Anthony West | Kawasaki Racing Team | 45'36.758 | 28 | 3 | 18 |
| 14 | 21 | John Hopkins | Kawasaki Racing Team | 45'37.038 | 28 | 2 | 17 |
| 15 | 1 | Casey Stoner | Ducati Marlboro Team | 11'11.968 | 21 | 0 | 1 |
| 16 | 15 | Alex De Angelis | San Carlo Honda Gresini | 1'46.395 | 27 | 0 | 13 |
| 17 | 69 | Nicky Hayden | Repsol Honda Team | 0 | 0 | 16 | |
| 18 | 14 | Randy De Puniet | LCR Honda MotoGP | 28 | 0 | 4 |