Course disputée sur le circuit de Mugello
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 26 | Dani Pedrosa | Repsol Honda Team | 12:47:46 | 23 | 25 | 1 |
| 2 | 99 | Jorge Lorenzo | Fiat Yamaha Team | 13:54:40 | 23 | 20 | 2 |
| 3 | 4 | Andrea Dovizioso | Repsol Honda Team | 14:31:02 | 23 | 16 | 8 |
| 4 | 27 | Casey Stoner | Ducati Marlboro Team | 19:56:09 | 23 | 13 | 3 |
| 5 | 33 | Marco Melandri | San Carlo Honda Gresini | 19:56:41 | 23 | 11 | 14 |
| 6 | 14 | Randy De Puniet | LCR Honda MotoGP | 20:00:31 | 23 | 10 | 6 |
| 7 | 11 | Ben Spies | Tech3 Yamaha | 20:47:52 | 23 | 9 | 7 |
| 8 | 41 | Aleix Espargaro | Pramac Racing | 23:57:18 | 23 | 8 | 9 |
| 9 | 58 | Marco Simoncelli | San Carlo Honda Gresini | 00:17:40 | 23 | 7 | 11 |
| 10 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 00:29:33 | 23 | 6 | 12 |
| 11 | 7 | Hiroshi Aoyama | Interwetten Honda MotoGP | 00:46:01 | 23 | 5 | 10 |
| 12 | 40 | Hector Barbera | Paginas Amarillas Aspar | 00:50:29 | 23 | 4 | 13 |
| 13 | 5 | Colin Edwards | Tech3 Yamaha | 09:27:39 | 23 | 3 | 5 |
| 14 | 19 | Alvaro Bautista | Rizla Suzuki MotoGP | 12:14:15 | 23 | 2 | 16 |
| 15 | 36 | Mika Kallio | Pramac Racing | 12:42:28 | 15 | 0 | 15 |
| 16 | 69 | Nicky Hayden | Ducati Marlboro Team | 13:41:03 | 18 | 0 | 4 |