Course disputée sur le circuit de Misano World Circuit Marco Simoncelli
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 26 | Dani Pedrosa | Repsol Honda Team | 20:27:39 | 28 | 25 | 1 |
| 2 | 99 | Jorge Lorenzo | Fiat Yamaha Team | 20:59:19 | 28 | 20 | 2 |
| 3 | 46 | Valentino Rossi | Fiat Yamaha Team | 21:20:42 | 28 | 16 | 4 |
| 4 | 4 | Andrea Dovizioso | Repsol Honda Team | 21:20:42 | 28 | 13 | 8 |
| 5 | 27 | Casey Stoner | Ducati Marlboro Team | 01:35:38 | 28 | 11 | 3 |
| 6 | 11 | Ben Spies | Tech3 Yamaha | 04:20:44 | 28 | 10 | 5 |
| 7 | 5 | Colin Edwards | Tech3 Yamaha | 06:09:53 | 28 | 9 | 7 |
| 8 | 19 | Alvaro Bautista | Rizla Suzuki MotoGP | 07:03:36 | 28 | 8 | 16 |
| 9 | 40 | Hector Barbera | Paginas Amarillas Aspar | 07:50:02 | 28 | 7 | 12 |
| 10 | 33 | Marco Melandri | San Carlo Honda Gresini | 08:13:56 | 28 | 6 | 10 |
| 11 | 41 | Aleix Espargaro | Pramac Racing | 09:12:45 | 28 | 5 | 15 |
| 12 | 7 | Hiroshi Aoyama | Interwetten Honda MotoGP | 09:20:53 | 28 | 4 | 13 |
| 13 | 14 | Randy De Puniet | LCR Honda MotoGP | 10:29:00 | 28 | 3 | 6 |
| 14 | 58 | Marco Simoncelli | San Carlo Honda Gresini | 19:33:22 | 28 | 2 | 9 |
| 15 | 36 | Mika Kallio | Pramac Racing | 07:30:43 | 17 | 0 | 17 |
| 16 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 08:07:24 | 2 | 0 | 11 |
| 17 | 69 | Nicky Hayden | Ducati Marlboro Team | 01:00:00 | 0 | 0 | 14 |