Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 26 | Dani Pedrosa | Repsol Honda Team | 01:06:55 | 28 | 25 | 5 |
| 2 | 11 | Ben Spies | Tech3 Yamaha | 02:06:30 | 28 | 20 | 1 |
| 3 | 99 | Jorge Lorenzo | Fiat Yamaha Team | 03:00:27 | 28 | 16 | 2 |
| 4 | 46 | Valentino Rossi | Fiat Yamaha Team | 04:37:28 | 28 | 13 | 7 |
| 5 | 4 | Andrea Dovizioso | Repsol Honda Team | 07:11:40 | 28 | 11 | 4 |
| 6 | 69 | Nicky Hayden | Ducati Marlboro Team | 10:52:33 | 28 | 10 | 3 |
| 7 | 58 | Marco Simoncelli | San Carlo Honda Gresini | 11:19:15 | 28 | 9 | 8 |
| 8 | 19 | Alvaro Bautista | Rizla Suzuki MotoGP | 11:20:40 | 28 | 8 | 11 |
| 9 | 41 | Aleix Espargaro | Pramac Racing | 13:35:20 | 28 | 7 | 14 |
| 10 | 40 | Hector Barbera | Paginas Amarillas Aspar | 15:23:03 | 28 | 6 | 16 |
| 11 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 16:30:01 | 28 | 5 | 10 |
| 12 | 7 | Hiroshi Aoyama | Interwetten Honda MotoGP | 17:11:58 | 28 | 4 | 13 |
| 13 | 14 | Randy De Puniet | LCR Honda MotoGP | 18:55:54 | 28 | 3 | 17 |
| 14 | 36 | Mika Kallio | Pramac Racing | 13:01:34 | 18 | 0 | 15 |
| 15 | 5 | Colin Edwards | Tech3 Yamaha | 23:37:46 | 16 | 0 | 9 |
| 16 | 27 | Casey Stoner | Ducati Marlboro Team | 09:23:43 | 7 | 0 | 6 |
| 17 | 33 | Marco Melandri | San Carlo Honda Gresini | 11:46:25 | 2 | 0 | 12 |