Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 26 | Dani Pedrosa | Repsol Honda Team | 47'31.615 | 28 | 25 | 5 |
| 2 | 11 | Ben Spies | Tech3 Yamaha | 47'35.190 | 28 | 20 | 1 |
| 3 | 99 | Jorge Lorenzo | Fiat Yamaha Team | 47'38.427 | 28 | 16 | 2 |
| 4 | 46 | Valentino Rossi | Fiat Yamaha Team | 47'44.248 | 28 | 13 | 7 |
| 5 | 4 | Andrea Dovizioso | Repsol Honda Team | 47'53.500 | 28 | 11 | 4 |
| 6 | 69 | Nicky Hayden | Ducati Marlboro Team | 48'06.753 | 28 | 10 | 3 |
| 7 | 58 | Marco Simoncelli | San Carlo Honda Gresini | 48'08.355 | 28 | 9 | 8 |
| 8 | 19 | Alvaro Bautista | Rizla Suzuki MotoGP | 48'08.440 | 28 | 8 | 11 |
| 9 | 41 | Aleix Espargaro | Pramac Racing | 48'16.520 | 28 | 7 | 14 |
| 10 | 40 | Hector Barbera | Paginas Amarillas Aspar | 48'22.983 | 28 | 6 | 16 |
| 11 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 48'27.001 | 28 | 5 | 10 |
| 12 | 7 | Hiroshi Aoyama | Interwetten Honda MotoGP | 48'29.518 | 28 | 4 | 13 |
| 13 | 14 | Randy De Puniet | LCR Honda MotoGP | 48'35.754 | 28 | 3 | 17 |
| 14 | 36 | Mika Kallio | Pramac Racing | 30'57.694 | 18 | 0 | 15 |
| 15 | 5 | Colin Edwards | Tech3 Yamaha | 30'09.466 | 16 | 0 | 9 |
| 16 | 27 | Casey Stoner | Ducati Marlboro Team | 12'01.423 | 7 | 0 | 6 |
| 17 | 33 | Marco Melandri | San Carlo Honda Gresini | 3'31.585 | 2 | 0 | 12 |