Course disputée sur le circuit de Laguna-seca
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 27 | Casey Stoner | Repsol Honda Team | 12:09:05 | 32 | 25 | 2 |
| 2 | 1 | Jorge Lorenzo | Yamaha Factory Racing | 13:42:59 | 32 | 20 | 1 |
| 3 | 26 | Dani Pedrosa | Repsol Honda Team | 14:46:52 | 32 | 16 | 3 |
| 4 | 11 | Ben Spies | Yamaha Factory Racing | 17:51:47 | 32 | 13 | 4 |
| 5 | 4 | Andrea Dovizioso | Repsol Honda Team | 17:57:10 | 32 | 11 | 6 |
| 6 | 46 | Valentino Rossi | Ducati Team | 20:34:56 | 32 | 10 | 7 |
| 7 | 69 | Nicky Hayden | Ducati Team | 20:46:16 | 32 | 9 | 9 |
| 8 | 5 | Colin Edwards | Monster Yamaha Tech 3 | 00:47:27 | 32 | 8 | 11 |
| 9 | 8 | Hector Barbera | Mapfre Aspar Team MotoGP | 02:28:14 | 32 | 7 | 8 |
| 10 | 7 | Hiroshi Aoyama | San Carlo Honda Gresini | 07:16:35 | 32 | 6 | 7 |
| 11 | 17 | Karel Abraham | Cardion AB Motoracing | 07:21:17 | 32 | 5 | 13 |
| 12 | 65 | Loris Capirossi | Pramac Racing Team | 15:45:29 | 31 | 4 | 16 |
| 13 | 24 | Toni Elias | LCR Honda MotoGP | 22:39:22 | 31 | 3 | 17 |
| 14 | 19 | Alvaro Bautista | Rizla Suzuki MotoGP | 14:53:02 | 13 | 0 | 12 |
| 15 | 23 | Ben Bostrom | LCR Honda MotoGP | 11:30:42 | 8 | 0 | 18 |
| 16 | 58 | Marco Simoncelli | San Carlo Honda Gresini | 20:11:41 | 6 | 0 | 5 |
| 17 | 35 | Cal Crutchlow | Monster Yamaha Tech 3 | 00:49:14 | 3 | 0 | 10 |