Course disputée sur le circuit de Misano World Circuit Marco Simoncelli
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 1 | Jorge Lorenzo | Yamaha Factory Racing | 17:37:57 | 28 | 25 | 2 |
| 2 | 26 | Dani Pedrosa | Repsol Honda Team | 19:39:36 | 28 | 20 | 3 |
| 3 | 27 | Casey Stoner | Repsol Honda Team | 20:57:24 | 28 | 16 | 1 |
| 4 | 58 | Marco Simoncelli | San Carlo Honda Gresini | 22:27:10 | 28 | 13 | 5 |
| 5 | 4 | Andrea Dovizioso | Repsol Honda Team | 22:27:47 | 28 | 11 | 6 |
| 6 | 11 | Ben Spies | Yamaha Factory Racing | 22:39:29 | 28 | 10 | 4 |
| 7 | 46 | Valentino Rossi | Ducati Team | 00:13:00 | 28 | 9 | 11 |
| 8 | 19 | Alvaro Bautista | Rizla Suzuki MotoGP | 02:09:15 | 28 | 8 | 8 |
| 9 | 8 | Hector Barbera | Mapfre Aspar Team MotoGP | 04:02:59 | 28 | 7 | 9 |
| 10 | 35 | Cal Crutchlow | Monster Yamaha Tech 3 | 04:06:37 | 28 | 6 | 13 |
| 11 | 7 | Hiroshi Aoyama | San Carlo Honda Gresini | 04:37:05 | 28 | 5 | 10 |
| 12 | 17 | Karel Abraham | Cardion AB Motoracing | 04:53:03 | 28 | 4 | 12 |
| 13 | 5 | Colin Edwards | Monster Yamaha Tech 3 | 08:27:06 | 28 | 3 | 7 |
| 14 | 14 | Randy De Puniet | Pramac Racing Team | 10:57:23 | 28 | 2 | 14 |
| 15 | 24 | Toni Elias | LCR Honda MotoGP | 15:53:53 | 28 | 1 | 17 |
| 16 | 65 | Loris Capirossi | Pramac Racing Team | 17:04:28 | 8 | 0 | 16 |
| 17 | 69 | Nicky Hayden | Ducati Team | 08:49:44 | 2 | 0 | 15 |