Course disputée sur le circuit de Estoril
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 26 | Dani Pedrosa | Repsol Honda Team | 21:18:03 | 28 | 25 | 3 |
| 2 | 1 | Jorge Lorenzo | Yamaha Factory Racing | 22:08:54 | 28 | 20 | 1 |
| 3 | 27 | Casey Stoner | Repsol Honda Team | 23:25:41 | 28 | 16 | 4 |
| 4 | 4 | Andrea Dovizioso | Repsol Honda Team | 01:53:33 | 28 | 13 | 6 |
| 5 | 46 | Valentino Rossi | Ducati Team | 01:53:58 | 28 | 11 | 9 |
| 6 | 5 | Colin Edwards | Monster Yamaha Tech 3 | 06:20:58 | 28 | 10 | 7 |
| 7 | 7 | Hiroshi Aoyama | San Carlo Honda Gresini | 08:03:52 | 28 | 9 | 11 |
| 8 | 35 | Cal Crutchlow | Monster Yamaha Tech 3 | 08:39:55 | 28 | 8 | 8 |
| 9 | 69 | Nicky Hayden | Ducati Team | 12:32:50 | 28 | 7 | 13 |
| 10 | 14 | Randy De Puniet | Pramac Racing Team | 13:53:00 | 28 | 6 | 16 |
| 11 | 24 | Toni Elias | LCR Honda MotoGP | 14:04:17 | 28 | 5 | 17 |
| 12 | 65 | Loris Capirossi | Pramac Racing Team | 14:27:56 | 28 | 4 | 14 |
| 13 | 19 | Alvaro Bautista | Rizla Suzuki MotoGP | 20:44:13 | 28 | 3 | 15 |
| 14 | 11 | Ben Spies | Yamaha Factory Racing | 00:04:16 | 12 | 0 | 5 |
| 15 | 17 | Karel Abraham | Cardion AB Motoracing | 07:37:19 | 1 | 0 | 12 |
| 16 | 58 | Marco Simoncelli | San Carlo Honda Gresini | 01:00:00 | 0 | 0 | 2 |
| 17 | 8 | Hector Barbera | Mapfre Aspar Team MotoGP | 01:00:00 | 0 | 0 | 10 |