Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 27 | Casey Stoner | Repsol Honda Team | 14:19:46 | 28 | 25 | 1 |
| 2 | 26 | Dani Pedrosa | Repsol Honda Team | 15:40:14 | 28 | 20 | 4 |
| 3 | 11 | Ben Spies | Yamaha Factory Racing | 17:16:29 | 28 | 16 | 2 |
| 4 | 1 | Jorge Lorenzo | Yamaha Factory Racing | 18:56:02 | 28 | 13 | 3 |
| 5 | 4 | Andrea Dovizioso | Repsol Honda Team | 19:06:28 | 28 | 11 | 5 |
| 6 | 19 | Alvaro Bautista | Rizla Suzuki MotoGP | 22:47:13 | 28 | 10 | 9 |
| 7 | 5 | Colin Edwards | Monster Yamaha Tech 3 | 01:21:16 | 28 | 9 | 6 |
| 8 | 14 | Randy De Puniet | Pramac Racing Team | 05:10:02 | 28 | 8 | 46 |
| 9 | 7 | Hiroshi Aoyama | San Carlo Honda Gresini | 05:16:16 | 28 | 7 | 13 |
| 10 | 46 | Valentino Rossi | Ducati Team | 05:42:11 | 28 | 6 | 14 |
| 11 | 35 | Cal Crutchlow | Monster Yamaha Tech 3 | 06:12:50 | 28 | 5 | 11 |
| 12 | 58 | Marco Simoncelli | San Carlo Honda Gresini | 07:02:07 | 28 | 4 | 7 |
| 13 | 24 | Toni Elias | LCR Honda MotoGP | 07:35:55 | 28 | 3 | 15 |
| 14 | 69 | Nicky Hayden | Ducati Team | 03:08:56 | 26 | 2 | 8 |
| 15 | 8 | Hector Barbera | Mapfre Aspar Team MotoGP | 00:38:30 | 27 | 0 | 10 |
| 16 | 17 | Karel Abraham | Cardion AB Motoracing | 01:48:36 | 20 | 0 | 16 |
| 17 | 65 | Loris Capirossi | Pramac Racing Team | 08:10:40 | 14 | 0 | 17 |