Course disputée sur le circuit de Mugello
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 46 | Valentino Rossi | Fiat Yamaha Team | 16:46:25 | 23 | 25 | 3 |
| 2 | 26 | Dani Pedrosa | Repsol Honda Team | 17:37:39 | 23 | 20 | 8 |
| 3 | 4 | Alex Barros | Pramac d\'Antin | 18:25:41 | 23 | 16 | 10 |
| 4 | 27 | Casey Stoner | Ducati Marlboro Team | 18:26:37 | 23 | 13 | 1 |
| 5 | 21 | John Hopkins | Rizla Suzuki MotoGP | 20:27:09 | 23 | 11 | 9 |
| 6 | 24 | Toni Elias | San Carlo Honda Gresini | 22:07:20 | 23 | 10 | 15 |
| 7 | 65 | Loris Capirossi | Ducati Marlboro Team | 22:13:51 | 23 | 9 | 5 |
| 8 | 71 | Chris Vermeulen | Rizla Suzuki MotoGP | 23:06:35 | 23 | 8 | 2 |
| 9 | 33 | Marco Melandri | San Carlo Honda Gresini | 23:07:02 | 23 | 7 | 6 |
| 10 | 1 | Nicky Hayden | Repsol Honda Team | 23:33:18 | 23 | 6 | 13 |
| 11 | 66 | Alexander Hofmann | Pramac d\'Antin | 23:39:26 | 23 | 5 | 11 |
| 12 | 5 | Colin Edwards | Fiat Yamaha Team | 00:33:06 | 23 | 4 | 16 |
| 13 | 56 | Shinya Nakano | Konica Minolta Honda | 02:58:38 | 23 | 3 | 12 |
| 14 | 50 | Sylvain Guintoli | Tech3 Yamaha | 05:18:03 | 23 | 2 | 17 |
| 15 | 6 | Makoto Tamada | Tech3 Yamaha | 05:18:50 | 23 | 1 | 20 |
| 16 | 19 | Olivier Jacque | Kawasaki Racing Team | 05:20:02 | 23 | 0 | 4 |
| 17 | 10 | Kenny Jr Roberts | Team Roberts | 17:00:07 | 23 | 0 | 18 |
| 18 | 7 | Carlos Checa | LCR Honda MotoGP | 20:04:25 | 14 | 0 | 14 |
| 19 | 80 | Kurtis Roberts | Team Roberts | 05:10:21 | 20 | 0 | 19 |
| 20 | 14 | Randy De Puniet | Kawasaki Racing Team | 10:28:43 | 22 | 0 | 7 |