Course disputée sur le circuit de Misano World Circuit Marco Simoncelli
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 27 | Casey Stoner | Ducati Marlboro Team | 23:58:40 | 28 | 25 | 1 |
| 2 | 71 | Chris Vermeulen | Rizla Suzuki MotoGP | 01:19:31 | 28 | 20 | 8 |
| 3 | 21 | John Hopkins | Rizla Suzuki MotoGP | 04:25:22 | 28 | 16 | 5 |
| 4 | 33 | Marco Melandri | San Carlo Honda Gresini | 06:17:37 | 28 | 13 | 12 |
| 5 | 65 | Loris Capirossi | Ducati Marlboro Team | 06:51:47 | 28 | 11 | 13 |
| 6 | 7 | Carlos Checa | LCR Honda MotoGP | 09:41:46 | 28 | 10 | 7 |
| 7 | 24 | Toni Elias | San Carlo Honda Gresini | 11:20:16 | 28 | 9 | 15 |
| 8 | 13 | Anthony West | Kawasaki Racing Team | 11:34:54 | 28 | 8 | 10 |
| 9 | 5 | Colin Edwards | Fiat Yamaha Team | 13:04:26 | 28 | 7 | 9 |
| 10 | 56 | Shinya Nakano | Konica Minolta Honda | 13:32:08 | 28 | 6 | 14 |
| 11 | 66 | Alexander Hofmann | Pramac d\'Antin | 13:40:19 | 28 | 5 | 19 |
| 12 | 50 | Sylvain Guintoli | Tech3 Yamaha | 19:11:36 | 28 | 4 | 11 |
| 13 | 1 | Nicky Hayden | Repsol Honda Team | 22:19:04 | 28 | 3 | 3 |
| 14 | 6 | Makoto Tamada | Tech3 Yamaha | 02:09:03 | 28 | 2 | 16 |
| 15 | 80 | Kurtis Roberts | Team Roberts | 11:06:35 | 27 | 1 | 18 |
| 16 | 4 | Alex Barros | Pramac d\'Antin | 21:49:21 | 13 | 0 | 17 |
| 17 | 46 | Valentino Rossi | Fiat Yamaha Team | 06:28:03 | 23 | 0 | 2 |
| 18 | 14 | Randy De Puniet | Kawasaki Racing Team | 01:00:00 | 0 | 0 | 4 |
| 19 | 26 | Dani Pedrosa | Repsol Honda Team | 01:00:00 | 0 | 0 | 6 |