Course disputée sur le circuit de Misano World Circuit Marco Simoncelli
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 46 | Valentino Rossi | Fiat Yamaha Team | 23:28:02 | 28 | 25 | 1 |
| 2 | 99 | Jorge Lorenzo | Fiat Yamaha Team | 00:08:18 | 28 | 20 | 3 |
| 3 | 3 | Dani Pedrosa | Repsol Honda Team | 02:54:42 | 28 | 16 | 2 |
| 4 | 4 | Andrea Dovizioso | Repsol Honda Team | 06:46:52 | 28 | 13 | 8 |
| 5 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 06:50:21 | 28 | 11 | 10 |
| 6 | 24 | Toni Elias | San Carlo Honda Gresini | 07:19:28 | 28 | 10 | 4 |
| 7 | 36 | Mika Kallio | Pramac Racing | 07:51:06 | 28 | 9 | 11 |
| 8 | 33 | Marco Melandri | Kawasaki Racing Team | 08:17:19 | 28 | 8 | 12 |
| 9 | 7 | Chris Vermeulen | Rizla Suzuki MotoGP | 08:19:51 | 28 | 7 | 13 |
| 10 | 52 | James Toseland | Tech3 Yamaha | 10:07:09 | 28 | 6 | 14 |
| 11 | 44 | Aleix Espargaro | Pramac d\'Antin | 12:25:55 | 28 | 5 | 15 |
| 12 | 14 | Randy De Puniet | LCR Honda MotoGP | 13:55:23 | 28 | 4 | 9 |
| 13 | 88 | Niccolo Canepa | Pramac Racing | 17:01:20 | 28 | 3 | 16 |
| 14 | 41 | Gabor Talmacsi | Scot Racing Team MotoGP | 22:20:29 | 28 | 2 | 17 |
| 15 | 5 | Colin Edwards | Tech3 Yamaha | 01:00:00 | 0 | 0 | 5 |
| 16 | 69 | Nicky Hayden | Ducati Marlboro Team | 01:00:00 | 0 | 0 | 6 |
| 17 | 15 | Alex De Angelis | San Carlo Honda Gresini | 01:00:00 | 0 | 0 | 7 |