Course disputée sur le circuit de Estoril
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 99 | Jorge Lorenzo | Fiat Yamaha Team | 16:52:02 | 28 | 25 | 1 |
| 2 | 27 | Casey Stoner | Ducati Marlboro Team | 18:36:56 | 28 | 20 | 3 |
| 3 | 3 | Dani Pedrosa | Repsol Honda Team | 19:36:51 | 28 | 16 | 4 |
| 4 | 46 | Valentino Rossi | Fiat Yamaha Team | 23:22:30 | 28 | 13 | 2 |
| 5 | 5 | Colin Edwards | Tech3 Yamaha | 01:56:14 | 28 | 11 | 5 |
| 6 | 24 | Toni Elias | San Carlo Honda Gresini | 02:47:11 | 28 | 10 | 13 |
| 7 | 4 | Andrea Dovizioso | Repsol Honda Team | 02:47:25 | 28 | 9 | 8 |
| 8 | 69 | Nicky Hayden | Ducati Marlboro Team | 03:39:12 | 28 | 8 | 9 |
| 9 | 52 | James Toseland | Tech3 Yamaha | 05:06:55 | 28 | 7 | 12 |
| 10 | 7 | Chris Vermeulen | Rizla Suzuki MotoGP | 07:33:05 | 28 | 6 | 15 |
| 11 | 14 | Randy De Puniet | LCR Honda MotoGP | 08:20:20 | 28 | 5 | 6 |
| 12 | 33 | Marco Melandri | Kawasaki Racing Team | 10:47:17 | 28 | 4 | 16 |
| 13 | 88 | Niccolo Canepa | Pramac Racing | 10:47:40 | 28 | 3 | 14 |
| 14 | 41 | Gabor Talmacsi | Scot Racing Team MotoGP | 17:07:01 | 28 | 2 | 17 |
| 15 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 05:38:07 | 20 | 0 | 7 |
| 16 | 15 | Alex De Angelis | San Carlo Honda Gresini | 14:07:16 | 8 | 0 | 11 |
| 17 | 36 | Mika Kallio | Pramac Racing | 19:28:37 | 5 | 0 | 10 |