Course disputée sur le circuit de Estoril
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 99 | Jorge Lorenzo | Fiat Yamaha Team | 45'35.522 | 28 | 25 | 1 |
| 2 | 27 | Casey Stoner | Ducati Marlboro Team | 45'41.816 | 28 | 20 | 3 |
| 3 | 3 | Dani Pedrosa | Repsol Honda Team | 45'45.411 | 28 | 16 | 4 |
| 4 | 46 | Valentino Rossi | Fiat Yamaha Team | 45'58.950 | 28 | 13 | 2 |
| 5 | 5 | Colin Edwards | Tech3 Yamaha | 46'08.174 | 28 | 11 | 5 |
| 6 | 24 | Toni Elias | San Carlo Honda Gresini | 46'11.231 | 28 | 10 | 13 |
| 7 | 4 | Andrea Dovizioso | Repsol Honda Team | 46'11.245 | 28 | 9 | 8 |
| 8 | 69 | Nicky Hayden | Ducati Marlboro Team | 46'14.352 | 28 | 8 | 9 |
| 9 | 52 | James Toseland | Tech3 Yamaha | 46'19.615 | 28 | 7 | 12 |
| 10 | 7 | Chris Vermeulen | Rizla Suzuki MotoGP | 46'28.385 | 28 | 6 | 15 |
| 11 | 14 | Randy De Puniet | LCR Honda MotoGP | 46'31.220 | 28 | 5 | 6 |
| 12 | 33 | Marco Melandri | Kawasaki Racing Team | 46'40.037 | 28 | 4 | 16 |
| 13 | 88 | Niccolo Canepa | Pramac Racing | 46'40.060 | 28 | 3 | 14 |
| 14 | 41 | Gabor Talmacsi | Scot Racing Team MotoGP | 47'02.821 | 28 | 2 | 17 |
| 15 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 33'23.887 | 20 | 0 | 7 |
| 16 | 15 | Alex De Angelis | San Carlo Honda Gresini | 13'44.836 | 8 | 0 | 11 |
| 17 | 36 | Mika Kallio | Pramac Racing | 8'18.517 | 5 | 0 | 10 |