Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 99 | Jorge Lorenzo | Fiat Yamaha Team | 47'13.592 | 28 | 25 | 2 |
| 2 | 15 | Alex De Angelis | San Carlo Honda Gresini | 47'23.027 | 28 | 20 | 4 |
| 3 | 69 | Nicky Hayden | Ducati Marlboro Team | 47'26.539 | 28 | 16 | 6 |
| 4 | 4 | Andrea Dovizioso | Repsol Honda Team | 47'27.070 | 28 | 13 | 8 |
| 5 | 5 | Colin Edwards | Tech3 Yamaha | 47'39.846 | 28 | 11 | 5 |
| 6 | 52 | James Toseland | Tech3 Yamaha | 47'46.000 | 28 | 10 | 10 |
| 7 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 47'47.992 | 28 | 9 | 11 |
| 8 | 36 | Mika Kallio | Pramac Racing | 47'48.448 | 28 | 8 | 15 |
| 9 | 24 | Toni Elias | San Carlo Honda Gresini | 47'58.597 | 28 | 7 | 7 |
| 10 | 3 | Dani Pedrosa | Repsol Honda Team | 47'58.969 | 28 | 6 | 1 |
| 11 | 7 | Chris Vermeulen | Rizla Suzuki MotoGP | 47'59.070 | 28 | 5 | 14 |
| 12 | 14 | Randy De Puniet | LCR Honda MotoGP | 48'05.886 | 28 | 4 | 12 |
| 13 | 44 | Aleix Espargaro | Pramac d\'Antin | 48'17.144 | 28 | 3 | 16 |
| 14 | 41 | Gabor Talmacsi | Scot Racing Team MotoGP | 48'28.678 | 28 | 2 | 17 |
| 15 | 33 | Marco Melandri | Kawasaki Racing Team | 42'36.675 | 25 | 0 | 9 |
| 16 | 88 | Niccolo Canepa | Pramac Racing | 39'29.440 | 23 | 0 | 13 |
| 17 | 46 | Valentino Rossi | Fiat Yamaha Team | 21'16.362 | 12 | 0 | 3 |