Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 99 | Jorge Lorenzo | Fiat Yamaha Team | 20:06:32 | 28 | 25 | 2 |
| 2 | 15 | Alex De Angelis | San Carlo Honda Gresini | 22:43:47 | 28 | 20 | 4 |
| 3 | 69 | Nicky Hayden | Ducati Marlboro Team | 23:42:19 | 28 | 16 | 6 |
| 4 | 4 | Andrea Dovizioso | Repsol Honda Team | 23:51:10 | 28 | 13 | 8 |
| 5 | 5 | Colin Edwards | Tech3 Yamaha | 03:24:06 | 28 | 11 | 5 |
| 6 | 52 | James Toseland | Tech3 Yamaha | 05:06:40 | 28 | 10 | 10 |
| 7 | 65 | Loris Capirossi | Rizla Suzuki MotoGP | 05:39:52 | 28 | 9 | 11 |
| 8 | 36 | Mika Kallio | Pramac Racing | 05:47:28 | 28 | 8 | 15 |
| 9 | 24 | Toni Elias | San Carlo Honda Gresini | 08:36:37 | 28 | 7 | 7 |
| 10 | 3 | Dani Pedrosa | Repsol Honda Team | 08:42:49 | 28 | 6 | 1 |
| 11 | 7 | Chris Vermeulen | Rizla Suzuki MotoGP | 08:44:30 | 28 | 5 | 14 |
| 12 | 14 | Randy De Puniet | LCR Honda MotoGP | 10:38:06 | 28 | 4 | 12 |
| 13 | 44 | Aleix Espargaro | Pramac d\'Antin | 13:45:44 | 28 | 3 | 16 |
| 14 | 41 | Gabor Talmacsi | Scot Racing Team MotoGP | 16:57:58 | 28 | 2 | 17 |
| 15 | 33 | Marco Melandri | Kawasaki Racing Team | 15:11:15 | 25 | 0 | 9 |
| 16 | 88 | Niccolo Canepa | Pramac Racing | 11:10:40 | 23 | 0 | 13 |
| 17 | 46 | Valentino Rossi | Fiat Yamaha Team | 19:32:42 | 12 | 0 | 3 |