Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 93 | Marc Marquez | Repsol Honda Team | 06:57:21 | 27 | 25 | 1 |
| 2 | 99 | Jorge Lorenzo | Yamaha Factory Racing | 07:27:24 | 27 | 20 | 3 |
| 3 | 46 | Valentino Rossi | Yamaha Factory Racing | 08:46:39 | 27 | 16 | 5 |
| 4 | 26 | Dani Pedrosa | Repsol Honda Team | 09:44:17 | 27 | 13 | 8 |
| 5 | 44 | Pol Espargaro | Monster Yamaha Tech 3 | 11:54:08 | 27 | 11 | 6 |
| 6 | 38 | Bradley Smith | Monster Yamaha Tech 3 | 12:24:05 | 27 | 10 | 9 |
| 7 | 4 | Andrea Dovizioso | Ducati Team | 12:43:20 | 27 | 9 | 2 |
| 8 | 35 | Cal Crutchlow | Ducati Team | 18:00:37 | 27 | 8 | 12 |
| 9 | 45 | Scott Redding | Go&fun Honda Gresini | 18:12:28 | 27 | 7 | 11 |
| 10 | 7 | Hiroshi Aoyama | Power Electronics Aspar | 22:26:41 | 27 | 6 | 18 |
| 11 | 17 | Karel Abraham | Cardion AB Motoracing | 01:02:51 | 27 | 5 | 21 |
| 12 | 63 | Mike Di Meglio | Avintia Blusens | 01:06:27 | 27 | 4 | 19 |
| 13 | 5 | Colin Edwards | NGM Mobile Forward Racing | 02:06:00 | 27 | 3 | 15 |
| 14 | 70 | Michael Laverty | Paul Bird Racing (CRT) | 02:10:44 | 27 | 2 | 23 |
| 15 | 23 | Broc Parkes | Paul Bird Racing (CRT) | 08:07:34 | 27 | 1 | 22 |
| 16 | 2 | Leon Camier | Ioda Racing Project | 23:06:37 | 19 | 0 | 16 |
| 17 | 29 | Andrea Iannone | Pramac Racing | 08:56:39 | 14 | 0 | 7 |
| 18 | 6 | Stefan Bradl | LCR Honda MotoGP | 04:42:11 | 12 | 0 | 10 |
| 19 | 41 | Aleix Espargaro | NGM Mobile Forward Racing | 04:41:42 | 12 | 0 | 4 |
| 20 | 9 | Danilo Petrucci | Ioda Racing Project | 02:52:00 | 6 | 0 | 17 |
| 21 | 8 | Hector Barbera | Avintia Blusens | 16:27:40 | 5 | 0 | 20 |
| 22 | 68 | Yonny Hernandez | Pramac Racing | 01:00:00 | 0 | 0 | 13 |
| 23 | 19 | Alvaro Bautista | Go&fun Honda Gresini | 01:00:00 | 0 | 0 | 14 |