Course disputée sur le circuit de Austin - Circuit of the Americas United
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 93 | Marc Marquez | Repsol Honda Team | 06:57:10 | 21 | 25 | 1 |
| 2 | 26 | Dani Pedrosa | Repsol Honda Team | 08:05:54 | 21 | 20 | 2 |
| 3 | 4 | Andrea Dovizioso | Ducati Team | 12:46:46 | 21 | 16 | 10 |
| 4 | 6 | Stefan Bradl | LCR Honda MotoGP | 13:17:00 | 21 | 13 | 3 |
| 5 | 38 | Bradley Smith | Monster Yamaha Tech 3 | 13:19:53 | 21 | 11 | 8 |
| 6 | 44 | Pol Espargaro | Monster Yamaha Tech 3 | 14:19:57 | 21 | 10 | 11 |
| 7 | 29 | Andrea Iannone | Pramac Racing | 14:48:07 | 21 | 9 | 9 |
| 8 | 46 | Valentino Rossi | Yamaha Factory Racing | 19:35:49 | 21 | 8 | 6 |
| 9 | 41 | Aleix Espargaro | NGM Mobile Forward Racing | 20:10:35 | 21 | 7 | 4 |
| 10 | 99 | Jorge Lorenzo | Yamaha Factory Racing | 20:35:41 | 21 | 6 | 5 |
| 11 | 69 | Nicky Hayden | Power Electronics Aspar | 23:49:25 | 21 | 5 | 14 |
| 12 | 7 | Hiroshi Aoyama | Power Electronics Aspar | 00:43:04 | 21 | 4 | 16 |
| 13 | 68 | Yonny Hernandez | Pramac Racing | 01:39:23 | 21 | 3 | 15 |
| 14 | 17 | Karel Abraham | Cardion AB Motoracing | 07:23:22 | 21 | 2 | 17 |
| 15 | 8 | Hector Barbera | Avintia Blusens | 08:36:46 | 21 | 1 | 18 |
| 16 | 70 | Michael Laverty | Paul Bird Racing (CRT) | 08:39:33 | 21 | 0 | 20 |
| 17 | 9 | Danilo Petrucci | Ioda Racing Project | 10:30:06 | 21 | 0 | 22 |
| 18 | 63 | Mike Di Meglio | Avintia Blusens | 14:03:12 | 21 | 0 | 23 |
| 19 | 45 | Scott Redding | Go&fun Honda Gresini | 03:38:01 | 19 | 0 | 13 |
| 20 | 5 | Colin Edwards | NGM Mobile Forward Racing | 05:53:13 | 17 | 0 | 19 |
| 21 | 35 | Cal Crutchlow | Ducati Team | 02:55:14 | 12 | 0 | 7 |
| 22 | 19 | Alvaro Bautista | Go&fun Honda Gresini | 02:16:45 | 9 | 0 | 12 |
| 23 | 23 | Broc Parkes | Paul Bird Racing (CRT) | 04:24:13 | 8 | 0 | 21 |