Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 93 | Marc Marquez | Repsol Honda Team | 04:54:23 | 27 | 25 | 1 |
| 2 | 26 | Dani Pedrosa | Repsol Honda Team | 05:52:38 | 27 | 20 | 3 |
| 3 | 99 | Jorge Lorenzo | Yamaha Factory Racing | 06:29:27 | 27 | 16 | 2 |
| 4 | 46 | Valentino Rossi | Yamaha Factory Racing | 10:25:58 | 27 | 13 | 9 |
| 5 | 35 | Cal Crutchlow | Tech3 Yamaha | 10:26:58 | 27 | 11 | 4 |
| 6 | 19 | Alvaro Bautista | Honda Gresini | 10:28:44 | 27 | 10 | 5 |
| 7 | 6 | Stefan Bradl | LCR Honda MotoGP | 11:48:25 | 27 | 9 | 8 |
| 8 | 38 | Bradley Smith | Monster Yamaha Tech 3 | 16:12:33 | 27 | 8 | 7 |
| 9 | 69 | Nicky Hayden | Ducati Team | 16:12:44 | 27 | 7 | 6 |
| 10 | 4 | Andrea Dovizioso | Ducati Team | 16:14:46 | 27 | 6 | 10 |
| 11 | 29 | Andrea Iannone | Energy T.i. Pramac Racing | 21:28:51 | 27 | 5 | 11 |
| 12 | 41 | Aleix Espargaro | Aspar Team MotoGP (CRT) | 23:25:13 | 27 | 4 | 13 |
| 13 | 5 | Colin Edwards | Forward Racing (CRT) | 00:12:05 | 27 | 3 | 12 |
| 14 | 71 | Claudio Corti | NGM Mobile Forward Racing | 01:47:50 | 27 | 2 | 16 |
| 15 | 7 | Hiroshi Aoyama | Avintia Blusens (crt) | 03:10:22 | 27 | 1 | 19 |
| 16 | 8 | Hector Barbera | Avintia Blusens (crt) | 04:45:42 | 27 | 0 | 17 |
| 17 | 9 | Danilo Petrucci | Came Iodaracing Project (crt) | 05:47:59 | 27 | 0 | 14 |
| 18 | 70 | Michael Laverty | Paul Bird Racing (CRT) | 07:40:51 | 27 | 0 | 18 |
| 19 | 67 | Bryan Staring | Honda Gresini | 08:00:10 | 26 | 0 | 20 |
| 20 | 68 | Yonny Hernandez | Paul Bird Racing (CRT) | 07:35:00 | 17 | 0 | 21 |
| 21 | 52 | Karel Pesek | Came Iodaracing Project (crt) | 01:22:26 | 14 | 0 | 22 |
| 22 | 14 | Randy De Puniet | Aspar Team MotoGP (CRT) | 04:45:13 | 5 | 0 | 15 |
| 23 | 79 | Blake Young | Attack Performance | 01:00:00 | 0 | 0 | 23 |