Course disputée sur le circuit de Indianapolis
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 93 | Marc Marquez | Repsol Honda Team | 03:42:51 | 27 | 25 | 1 |
| 2 | 99 | Jorge Lorenzo | Movistar Yamaha Motogp | 03:54:19 | 27 | 20 | 3 |
| 3 | 46 | Valentino Rossi | Movistar Yamaha Motogp | 05:22:17 | 27 | 16 | 8 |
| 4 | 26 | Dani Pedrosa | Repsol Honda Team | 05:25:18 | 27 | 13 | 2 |
| 5 | 29 | Andrea Iannone | Ducati Team | 09:41:39 | 27 | 11 | 7 |
| 6 | 38 | Bradley Smith | Monster Yamaha Tech 3 | 09:45:22 | 27 | 10 | 6 |
| 7 | 44 | Pol Espargaro | Monster Yamaha Tech 3 | 12:09:09 | 27 | 9 | 11 |
| 8 | 35 | Cal Crutchlow | Cwm Lcr Honda | 12:29:38 | 27 | 8 | 4 |
| 9 | 4 | Andrea Dovizioso | Ducati Team | 12:49:52 | 27 | 7 | 10 |
| 10 | 9 | Danilo Petrucci | Pramac Racing | 13:18:08 | 27 | 6 | 5 |
| 11 | 25 | Maverick Viñales | Team Suzuki Ecstar | 14:33:01 | 27 | 5 | 9 |
| 12 | 68 | Yonny Hernandez | Pramac Racing | 15:19:46 | 27 | 4 | 15 |
| 13 | 45 | Scott Redding | Eg 0,0 Marc Vds | 17:39:40 | 27 | 3 | 13 |
| 14 | 41 | Aleix Espargaro | Team Suzuki Ecstar | 20:30:36 | 27 | 2 | 12 |
| 15 | 8 | Hector Barbera | Avintia Racing | 21:31:58 | 27 | 1 | 14 |
| 16 | 69 | Nicky Hayden | Aspar Motogp Team | 21:47:17 | 27 | 0 | 20 |
| 17 | 63 | Mike Di Meglio | Avintia Racing | 22:18:32 | 27 | 0 | 22 |
| 18 | 19 | Alvaro Bautista | Aprilia Racing Team Gresini | 00:13:53 | 27 | 0 | 18 |
| 19 | 50 | Eugene Laverty | Aspar Motogp Team | 01:34:37 | 27 | 0 | 19 |
| 20 | 6 | Stefan Bradl | Athinà Forward Racing | 01:51:41 | 27 | 0 | 17 |
| 21 | 15 | Alex De Angelis | Octo Iodaracing Team | 01:54:13 | 27 | 0 | 21 |
| 22 | 24 | Toni Elias | Ab Motoracing | 01:55:05 | 27 | 0 | 23 |
| 23 | 43 | Jack Miller | Cwm Lcr Honda | 19:05:15 | 7 | 0 | 16 |