Course disputée sur le circuit de Misano World Circuit Marco Simoncelli
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 93 | Marc Marquez | Repsol Honda Team | 11:59:23 | 27 | 25 | 5 |
| 2 | 20 | Fabio Quartararo | Petronas Yamaha Srt | 12:14:26 | 27 | 20 | 3 |
| 3 | 12 | Maverick Viñales | Yamaha Factory Racing | 12:26:39 | 27 | 16 | 1 |
| 4 | 46 | Valentino Rossi | Yamaha Factory Racing | 15:30:23 | 27 | 13 | 7 |
| 5 | 21 | Franco Morbidelli | Petronas Yamaha Srt | 15:32:17 | 27 | 11 | 4 |
| 6 | 4 | Andrea Dovizioso | Ducati Team | 15:48:27 | 27 | 10 | 6 |
| 7 | 44 | Pol Espargaro | Red Bull Ktm Factory Racing | 17:33:33 | 27 | 9 | 2 |
| 8 | 36 | Joan Mir | Team Suzuki Ecstar | 18:14:35 | 27 | 8 | 9 |
| 9 | 43 | Jack Miller | Alma Pramac Racing | 19:21:57 | 27 | 7 | 16 |
| 10 | 9 | Danilo Petrucci | Ducati Team | 20:43:39 | 27 | 6 | 17 |
| 11 | 5 | Johann Zarco | Red Bull Ktm Factory Racing | 20:59:11 | 27 | 5 | 11 |
| 12 | 41 | Aleix Espargaro | Aprilia Racing Team Gresini | 21:34:00 | 27 | 4 | 15 |
| 13 | 53 | Tito Rabat | Reale Avintia Racing | 21:48:08 | 27 | 3 | 22 |
| 14 | 99 | Jorge Lorenzo | Repsol Honda Team | 01:06:50 | 27 | 2 | 18 |
| 15 | 55 | Hafizh Syahrin | Ktm Tech 3 Racing | 05:17:23 | 27 | 1 | 20 |
| 16 | 88 | Miguel Oliveira | Ktm Tech 3 Racing | 06:49:54 | 27 | 0 | 19 |
| 17 | 17 | Karel Abraham | Reale Avintia Racing | 11:30:29 | 27 | 0 | 21 |
| 18 | 30 | Takaaki Nakagami | Lcr Honda Idemitsu | 23:46:47 | 26 | 0 | 10 |
| 19 | 35 | Cal Crutchlow | Lcr Honda Castrol | 08:28:05 | 22 | 0 | 14 |
| 20 | 51 | Michele Pirro | Ducati Team | 10:40:43 | 21 | 0 | 12 |
| 21 | 42 | Alex Rins | Team Suzuki Ecstar | 12:59:18 | 15 | 0 | 8 |
| 22 | 63 | Francesco Bagnaia | Alma Pramac Racing | 06:14:21 | 11 | 0 | 13 |