Course disputée sur le circuit de Austin - Circuit of the Americas United
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 42 | Alex Rins | Team Suzuki Ecstar | 00:58:19 | 20 | 25 | 7 |
| 2 | 46 | Valentino Rossi | Yamaha Factory Racing | 01:06:01 | 20 | 20 | 2 |
| 3 | 43 | Jack Miller | Alma Pramac Racing | 03:19:13 | 20 | 16 | 4 |
| 4 | 4 | Andrea Dovizioso | Ducati Team | 03:35:19 | 20 | 13 | 13 |
| 5 | 21 | Franco Morbidelli | Petronas Yamaha Srt | 05:58:40 | 20 | 11 | 10 |
| 6 | 9 | Danilo Petrucci | Ducati Team | 06:56:15 | 20 | 10 | 8 |
| 7 | 20 | Fabio Quartararo | Petronas Yamaha Srt | 08:13:30 | 20 | 9 | 9 |
| 8 | 44 | Pol Espargaro | Red Bull Ktm Factory Racing | 09:14:02 | 20 | 8 | 5 |
| 9 | 63 | Francesco Bagnaia | Alma Pramac Racing | 09:28:27 | 20 | 7 | 12 |
| 10 | 30 | Takaaki Nakagami | Lcr Honda Idemitsu | 09:35:10 | 20 | 6 | 15 |
| 11 | 12 | Maverick Viñales | Yamaha Factory Racing | 10:26:16 | 20 | 5 | 6 |
| 12 | 29 | Andrea Iannone | Aprilia Racing Team Gresini | 10:37:58 | 20 | 4 | 17 |
| 13 | 5 | Johann Zarco | Red Bull Ktm Factory Racing | 12:45:57 | 20 | 3 | 19 |
| 14 | 88 | Miguel Oliveira | Ktm Tech 3 Racing | 13:16:11 | 20 | 2 | 18 |
| 15 | 53 | Tito Rabat | Reale Avintia Racing | 13:22:02 | 20 | 1 | 22 |
| 16 | 17 | Karel Abraham | Reale Avintia Racing | 13:23:59 | 20 | 0 | 20 |
| 17 | 36 | Joan Mir | Team Suzuki Ecstar | 14:19:22 | 20 | 0 | 14 |
| 18 | 55 | Hafizh Syahrin | Ktm Tech 3 Racing | 19:46:22 | 20 | 0 | 21 |
| 19 | 99 | Jorge Lorenzo | Repsol Honda Team | 17:30:50 | 10 | 0 | 11 |
| 20 | 93 | Marc Marquez | Repsol Honda Team | 13:46:33 | 8 | 0 | 1 |
| 21 | 41 | Aleix Espargaro | Aprilia Racing Team Gresini | 01:17:07 | 5 | 0 | 16 |
| 22 | 35 | Cal Crutchlow | Lcr Honda Castrol | 06:44:40 | 5 | 0 | 3 |