Course disputée sur le circuit de Austin - Circuit of the Americas United
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 42 | Alex Rins | Team Suzuki Ecstar | 41'45.499 | 20 | 25 | 7 |
| 2 | 46 | Valentino Rossi | Yamaha Factory Racing | 41'45.961 | 20 | 20 | 2 |
| 3 | 43 | Jack Miller | Alma Pramac Racing | 41'53.953 | 20 | 16 | 4 |
| 4 | 4 | Andrea Dovizioso | Ducati Team | 41'54.919 | 20 | 13 | 13 |
| 5 | 21 | Franco Morbidelli | Petronas Yamaha Srt | 42'03.520 | 20 | 11 | 10 |
| 6 | 9 | Danilo Petrucci | Ducati Team | 42'06.975 | 20 | 10 | 8 |
| 7 | 20 | Fabio Quartararo | Petronas Yamaha Srt | 42'11.610 | 20 | 9 | 9 |
| 8 | 44 | Pol Espargaro | Red Bull Ktm Factory Racing | 42'15.242 | 20 | 8 | 5 |
| 9 | 63 | Francesco Bagnaia | Alma Pramac Racing | 42'16.107 | 20 | 7 | 12 |
| 10 | 30 | Takaaki Nakagami | Lcr Honda Idemitsu | 42'16.510 | 20 | 6 | 15 |
| 11 | 12 | Maverick Viñales | Yamaha Factory Racing | 42'19.576 | 20 | 5 | 6 |
| 12 | 29 | Andrea Iannone | Aprilia Racing Team Gresini | 42'20.278 | 20 | 4 | 17 |
| 13 | 5 | Johann Zarco | Red Bull Ktm Factory Racing | 42'27.957 | 20 | 3 | 19 |
| 14 | 88 | Miguel Oliveira | Ktm Tech 3 Racing | 42'29.771 | 20 | 2 | 18 |
| 15 | 53 | Tito Rabat | Reale Avintia Racing | 42'30.122 | 20 | 1 | 22 |
| 16 | 17 | Karel Abraham | Reale Avintia Racing | 42'30.239 | 20 | 0 | 20 |
| 17 | 36 | Joan Mir | Team Suzuki Ecstar | 42'33.562 | 20 | 0 | 14 |
| 18 | 55 | Hafizh Syahrin | Ktm Tech 3 Racing | 42'53.182 | 20 | 0 | 21 |
| 19 | 99 | Jorge Lorenzo | Repsol Honda Team | 21'09.050 | 10 | 0 | 11 |
| 20 | 93 | Marc Marquez | Repsol Honda Team | 16'36.393 | 8 | 0 | 1 |
| 21 | 41 | Aleix Espargaro | Aprilia Racing Team Gresini | 11'32.227 | 5 | 0 | 16 |
| 22 | 35 | Cal Crutchlow | Lcr Honda Castrol | 10'25.480 | 5 | 0 | 3 |