Course disputée sur le circuit de Mugello
| Position | Numéro | Pilote | Team | Temps | Tours | Points | Départ |
|---|---|---|---|---|---|---|---|
| 1 | 9 | Danilo Petrucci | Ducati Team | 21:43:14 | 23 | 25 | 3 |
| 2 | 93 | Marc Marquez | Repsol Honda Team | 21:43:57 | 23 | 20 | 1 |
| 3 | 4 | Andrea Dovizioso | Ducati Team | 21:48:52 | 23 | 16 | 9 |
| 4 | 42 | Alex Rins | Team Suzuki Ecstar | 21:52:09 | 23 | 13 | 13 |
| 5 | 30 | Takaaki Nakagami | Lcr Honda Idemitsu | 23:32:09 | 23 | 11 | 10 |
| 6 | 12 | Maverick Viñales | Yamaha Factory Racing | 23:47:55 | 23 | 10 | 7 |
| 7 | 7 | Michele Pirro | Mission Winnow Ducati | 01:24:42 | 23 | 9 | 12 |
| 8 | 35 | Cal Crutchlow | Lcr Honda Castrol | 01:35:31 | 23 | 8 | 6 |
| 9 | 44 | Pol Espargaro | Red Bull Ktm Factory Racing | 02:18:47 | 23 | 7 | 11 |
| 10 | 20 | Fabio Quartararo | Petronas Yamaha Srt | 02:43:08 | 23 | 6 | 2 |
| 11 | 41 | Aleix Espargaro | Aprilia Racing Team Gresini | 03:25:17 | 23 | 5 | 15 |
| 12 | 36 | Joan Mir | Team Suzuki Ecstar | 03:25:38 | 23 | 4 | 20 |
| 13 | 99 | Jorge Lorenzo | Repsol Honda Team | 03:30:07 | 23 | 3 | 17 |
| 14 | 17 | Karel Abraham | Reale Avintia Racing | 05:18:12 | 23 | 2 | 16 |
| 15 | 29 | Andrea Iannone | Aprilia Racing Team Gresini | 05:30:45 | 23 | 1 | 23 |
| 16 | 88 | Miguel Oliveira | Ktm Tech 3 Racing | 06:04:55 | 23 | 0 | 22 |
| 17 | 5 | Johann Zarco | Red Bull Ktm Factory Racing | 09:20:51 | 23 | 0 | 19 |
| 18 | 43 | Jack Miller | Alma Pramac Racing | 21:38:37 | 15 | 0 | 5 |
| 19 | 63 | Francesco Bagnaia | Alma Pramac Racing | 21:50:51 | 11 | 0 | 8 |
| 20 | 55 | Hafizh Syahrin | Ktm Tech 3 Racing | 12:32:17 | 9 | 0 | 21 |
| 21 | 46 | Valentino Rossi | Yamaha Factory Racing | 23:38:29 | 7 | 0 | 18 |
| 22 | 21 | Franco Morbidelli | Petronas Yamaha Srt | 09:18:36 | 5 | 0 | 4 |